Inflammation Support

Inflammation can have both positive and negative health effects. Acute inflammation works with the immune system to address infectious and non-infectious cellular damage (1). However, when inflammation becomes chronic, it can have a critical impact on your health. Numerous studies have shown a correlation between chronic inflammation and all-cause, cancer, cardiovascular, and cerebrovascular mortality (2-3)

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About the Protocol

Curcumin (Curcuma longa)- Curcumin Phytosome

Recommended Dose: 600–1,000 mg, total per day, minimum 8–10 weeks (4-5)

Thorne's Curcumin Phytosome is the most clinically studied curcumin on the market.

Helps maintain a balanced inflammatory response throughout the body, including in the joints, muscles, GI tract, liver, brain, eyes, and nerves.

Benefits of Curcumin Phytosome:

Joint Stiffness and Muscle Soreness

Reduces joint stiffness
Promotes flexibility
Provide relief from minor aches and muscle soreness
Protects muscles against exercise stress and helps reduce delayed onset muscle soreness (DOMS)
May reduce muscle injury from training or exertion
Helps protect muscle tissue from the effects of chronological age
Helps maintain a balanced inflammatory response throughout the body, including in the joints, muscles, GI tract, liver, brain, eyes, and nerves

Liver Support

Promotes healthy cholesterol metabolism and up-regulation of liver enzymes
Supports maintenance of normal blood sugar

Omega-3 fatty acids (EPA/DHA)- OmegaGenics EPA-DHA 1000 Fish Oil

Recommended Dose: 2.5 g, total per day, minimum 12 weeks(6-7)

OmegaGenics® Fish Oil EPA-DHA 1000 mg is a high-quality fish oil that provides 5-in-1 benefits. Each serving provides 710 mg of EPA and 290 mg of DHA from naturally sourced 100% wild-caught fish. Rigorously tested for 200 contaminants, including heavy metals, environmental toxins, & plasticizers from microplastics.

OmegaGenics 1000mg Fish Oil promotes

Strong and healthy heart
Eye health
Immune health
Musculoskeletal health
Brain health

Probiotics- MegaSporeBiotic

Recommended Dose: 1.6 × 109 CFU, total per day, minimum 8 weeks (8-9)

MegaSporeBiotic™ is a 100% spore-based, broad-spectrum probiotic shown to maintain healthy gut barrier function.
This unique all-spore formula effectively RECONDITIONS the gut by promoting microbial diversity and maintaining key health-promoting, commensal gut bacteria.
MegaSporeBiotic™ boasts a 5-year shelf-life, does not require refrigeration, and maintains a healthy gut microbiome.

Quercetin

Recommended Dose: ≥ 500 mg, total per day, minimum of 8 weeks (10-12)

Quercetin has been shown to be one of the most useful and physiologically active flavonoids. Quercetin helps support stable mast cells to promote healthy inflammatory balance. This potent bioflavonoid can be used for maintaining or supporting the proper levels of enzymes and physiologic factors necessary for normal respiratory and sinus health, to help support seasonal respiratory challenges.

References

1.Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L. (2018). Inflammatory responses and inflammation-associated diseases in organs. Oncotarget, 9(6), 7204–7218. https://doi.org/10.18632/oncotarget.23208 2.Proctor, M. J., McMillan, D. C., Horgan, P. G., Fletcher, C. D., Talwar, D., & Morrison, D. S. (2015). Systemic inflammation predicts all-cause mortality: A glasgow inflammation outcome study. PloS One, 10(3), e0116206. https://doi.org/10.1371/journal.pone.0116206 3.Sharif, S., Van der Graaf, Y., Cramer, M. J., Kapelle, L. J., de Borst, G. J., Visseren, F. L. J., Westerink, J., & SMART study group. (2021). Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes. Cardiovascular Diabetology, 20(1), 220. https://doi.org/10.1186/s12933-021-01409-0 4.Gorabi, A. M., Abbasifard, M., Imani, D., Aslani, S., Razi, B., Alizadeh, S., Bagheri-Hosseinabadi, Z., Sathyapalan, T., & Sahebkar, A. (2022). Effect of curcumin on C-reactive protein as a biomarker of systemic inflammation: An updated meta-analysis of randomized controlled trials. Phytotherapy Research, 36(1), 85–97. https://doi.org/10.1002/ptr.7284 5.Usharani, P., Mateen, A. A., Naidu, M. U. R., Raju, Y. S. N., & Chandra, N. (2008). Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: A randomized, parallel-group, placebo-controlled, 8-week study. Drugs in R&D, 9(4), 243–250. https://doi.org/10.2165/00126839-200809040-00004 6.Madison, A. A., Belury, M. A., Andridge, R., Renna, M. E., Rosie Shrout, M., Malarkey, W. B., Lin, J., Epel, E. S., & Kiecolt-Glaser, J. K. (2021). Omega-3 supplementation and stress reactivity of cellular aging biomarkers: An ancillary substudy of a randomized, controlled trial in midlife adults. Molecular Psychiatry, 26(7), 3034–3042. https://doi.org/10.1038/s41380-021-01077-2 7.Valle Flores, J. A., Fariño Cortéz, J. E., Mayner Tresol, G. A., Perozo Romero, J., Blasco Carlos, M., & Nestares, T. (2020). Oral supplementation with omega-3 fatty acids and inflammation markers in patients with chronic kidney disease in hemodialysis. Applied Physiology, Nutrition, and Metabolism, 45(8), 805–811. https://doi.org/10.1139/apnm-2019-0729 8.Moludi, J., Kafil, H. S., Qaisar, S. A., Gholizadeh, P., Alizadeh, M., & Vayghyan, H. J. (2021). Effect of probiotic supplementation along with calorie restriction on metabolic endotoxemia, and inflammation markers in coronary artery disease patients: A double blind placebo controlled randomized clinical trial. Nutrition Journal, 20(1), 47. https://doi.org/10.1186/s12937-021-00703-7 9.Raji Lahiji, M., Zarrati, M., Najafi, S., Yazdani, B., Cheshmazar, E., Razmpoosh, E., Janani, L., Raji Lahiji, M., & Shidfar, F. (2021). Effects of synbiotic supplementation on serum adiponectin and inflammation status of overweight and obese breast cancer survivors: A randomized, triple-blind, placebo-controlled trial. Supportive Care in Cancer, 29(7), 4147–4157. https://doi.org/10.1007/s00520-020-05926-8 10.Dehghani, F., Sezavar Seyedi Jandaghi, S. H., Janani, L., Sarebanhassanabadi, M., Emamat, H., & Vafa, M. (2021). Effects of quercetin supplementation on inflammatory factors and quality of life in post-myocardial infarction patients: A double blind, placebo-controlled, randomized clinical trial. Phytotherapy Research, 35(4), 2085–2098. https://doi.org/10.1002/ptr.6955 11.Ou, Q., Zheng, Z., Zhao, Y., & Lin, W. (2020). Impact of quercetin on systemic levels of inflammation: A meta-analysis of randomised controlled human trials. International Journal of Food Sciences and Nutrition, 71(2), 152–163. https://doi.org/10.1080/09637486.2019.1627515 12.Vaez, S., Parivr, K., Amidi, F., Rudbari, N. H., Moini, A., & Amini, N. (2023). Quercetin and polycystic ovary syndrome; inflammation, hormonal parameters and pregnancy outcome: A randomized clinical trial. American Journal of Reproductive Immunology , 89(3), e13644. https://doi.org/10.1111/aji.13644