Cholesterol Support | Elite Nutrition Serv

Cholesterol Protocol

High cholesterol is one of the key markers when evaluating risk of cardiovascular disease, stroke, and related problems. According to the National Health and Nutrition Examination Survey (NHANES), in 2015-2016, 12.5% of adults had high total cholesterol, with men having a higher rate of prevalence. In conjunction, 18% of adults had low high-density lipoprotein (HDL) cholesterol (1).

Achieving a healthy cholesterol level has a valuable impact on decreasing risk for these events, and every bit helps. A decrease of 1 mmol/L in total cholesterol correlates with lower ischemic heart disease mortality (2). Problems with blood pressure amplify the risks found with dyslipidemia and were found to proportionally impact risk reduction when lowering cholesterol (2).

Based on current research findings presented below, the ingredients in this protocol have demonstrated efficacy in improving cholesterol profile and potentially cardiovascular outcomes.

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About the Protocol

Red Yeast Rice

Recommended Dose: 1200-2400 mg, once per day, minimum 8 to 12 weeks (3)

Red Yeast Rice is our yeast (Monascus purpureus) product containing several compounds collectively known as monacolins, which are substances shown by clinical studies to support healthy blood lipids already in the normal range.
A meta-analysis showed that in several small trials, red yeast rice was found to have similar effects to statins in ability to improve cholesterol profile (4)

Ubiquinol Coenzyme Q10 (CoQ10)

Recommended Dose: 200 mg, once per day, minimum 3 months (5)

Ubiquinol CoQ10 is an activated form of CoEnzyme Q10 that offers similar benefits.

Benefits of Ubiquinol CoQ10:

Helps support both cellular energy and cardiovascular health, as an antioxidant against lipid peroxidation.
Supports healthy blood sugar levels already in the normal range. The ubiquinol form is thought to offer superior bioavailability.

Omega-3 Fatty Acids- ProOmega 2000

Recommended Dose: 2-4 g, total per day, minimum 3 months (Dose varies greatly based on EPA/DHA content) (6-8)

ProOmega® 2000 features a breakthrough omega-3 oil. Ultra-concentrated EPA+DHA in the highly absorbable, triglyceride molecular form. In a slightly larger soft gel, this powerful concentrate is ideal for patients’ requiring the highest levels EPA+DHA.

2000 mg EPA+DHA per serving
Highest-concentration triglyceride-form omega oil
Unmatched support for heart, brain, immune health, and more

Garlic (Allium sativum)

Recommended Dose: 400-600 mg, once per day, minimum 12 weeks (9-10)

Supports antioxidant defenses and cardiovascular health
Blend of garlic extract and aged fermented black garlic extract with enhanced stability
Standardized for S-allyl-cysteine

L-Carnitine- Acetyl L-Carnitine 800mg

Recommended Dose: 2 g per day, minimum of 12 weeks (11-12)

Acetyl L-Carnitine is the acetylated ester of L-carnitine, and plays an important role in the transfer and utilization of long-chain fatty acids, which are used in the production of energy.

Benefits of L-Carnitine:

Supports biosynthesis of acetylcholine, the most abundant neurotransmitter in the body
Supports brain health leading to improved cognitive and neurometabolic support
Regulates activities of vital organs and blood vessels and communication between nerves and muscles.

References

1.Products – Data Briefs – Number 290 – October 2017. (2019, June 6). https://www.cdc.gov/nchs/products/databriefs/db290.htm https://www.cdc.gov/nchs/products/databriefs/db290.htm 2.Prospective Studies Collaboration, Lewington, S., Whitlock, G., Clarke, R., Sherliker, P., Emberson, J., Halsey, J., Qizilbash, N., Peto, R., & Collins, R. (2007). Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. The Lancet, 370(9602), 1829–1839. https://pubmed.ncbi.nlm.nih.gov/18061058/ 3.Liu, J., Zhang, J., Shi, Y., Grimsgaard, S., Alraek, T., & Fønnebø, V. (2006). Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials. Chinese Medicine, 1, 4. https://pubmed.ncbi.nlm.nih.gov/17302963/ 4.Ong, Y. C., & Aziz, Z. (2016). Systematic review of red yeast rice compared with simvastatin in dyslipidaemia. Journal of Clinical Pharmacy and Therapeutics, 41(2), 170–179. https://pubmed.ncbi.nlm.nih.gov/26956355/ 5.Wang, T.-J., Lien, A. S.-Y., Chen, J.-L., Lin, C.-H., Yang, Y.-S., & Yang, S.-H. (2019). A Randomized Clinical Efficacy Trial of Red Yeast Rice (Monascus pilosus) Against Hyperlipidemia. The American Journal of Chinese Medicine, 47(2), 323–335. https://pubmed.ncbi.nlm.nih.gov/30871361/ 6.Tóth, Š., Šajty, M., Pekárová, T., Mughees, A., Štefanič, P., Katz, M., Spišáková, K., Pella, J., & Pella, D. (2017). Addition of omega-3 fatty acid and coenzyme Q10 to statin therapy in patients with combined dyslipidemia. Journal of Basic and Clinical Physiology and Pharmacology, 28(4), 327–336. https://pubmed.ncbi.nlm.nih.gov/28541926/ 7.Innes, J. K., & Calder, P. C. (2018). The Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Cardiometabolic Risk Factors: A Systematic Review. International Journal of Molecular Sciences, 19(2). https://doi.org/10.3390/ijms19020532 https://pubmed.ncbi.nlm.nih.gov/29425187/ 8.Kim, C. H., Han, K. A., Yu, J., Lee, S. H., Jeon, H. K., Kim, S. H., Kim, S. Y., Han, K. H., Won, K., Kim, D.-B., Lee, K.-J., Min, K., Byun, D. W., Lim, S.-W., Ahn, C. W., Kim, S., Hong, Y. J., Sung, J., Hur, S.-H., … Kim, H.-S. (2018). Efficacy and Safety of Adding Omega-3 Fatty Acids in Statin-treated Patients with Residual Hypertriglyceridemia: ROMANTIC (Rosuvastatin-OMAcor iN residual hyperTrIglyCeridemia), a Randomized, Double-blind, and Placebo-controlled Trial. Clinical Therapeutics, 40(1), 83–94. https://pubmed.ncbi.nlm.nih.gov/29223557/ 9.Szulińska, M., Kręgielska-Narożna, M., Świątek, J., Styś, P., Kuźnar-Kamińska, B., Jakubowski, H., Walkowiak, J., & Bogdański, P. (2018). Garlic extract favorably modifies markers of endothelial function in obese patients -randomized double blind placebo-controlled nutritional intervention. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 102, 792–797. https://pubmed.ncbi.nlm.nih.gov/29604599/ 10.Sobenin, I. A., Andrianova, I. V., Demidova, O. N., Gorchakova, T., & Orekhov, A. N. (2008). Lipid-lowering effects of time-released garlic powder tablets in double-blinded placebo-controlled randomized study. Journal of Atherosclerosis and Thrombosis, 15(6), 334–338. https://pubmed.ncbi.nlm.nih.gov/19060427/ ( 11.Florentin, M., Elisaf, M. S., Rizos, C. V., Nikolaou, V., Bilianou, E., Pitsavos, C., & Liberopoulos, E. N. (2017). L-Carnitine/Simvastatin Reduces Lipoprotein (a) Levels Compared with Simvastatin Monotherapy: A Randomized Double-Blind Placebo-Controlled Study. Lipids, 52(1), 1–9. https://pubmed.ncbi.nlm.nih.gov/27914033/ 12.Malaguarnera, M., Vacante, M., Avitabile, T., Malaguarnera, M., Cammalleri, L., & Motta, M. (2009). L-Carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes. The American Journal of Clinical Nutrition, 89(1), 71–76. https://pubmed.ncbi.nlm.nih.gov/19056606/