Blood Pressure Support | Elite Nutrition Serv

Blood Pressure Protocol

Blood pressure homeostasis is a clear indication of health. Approximately 9 million deaths due to high blood pressure occur each year (1). This makes essential hypertension the most prominent disease worldwide. Uncontrolled blood pressure increases the risk for heart-related problems such as stroke, coronary artery disease, and heart failure. When left untreated, high blood pressure may lead to chronic kidney disease, disability, and even death (2).

Interventions aimed at lowering blood pressure improve comorbidities and outcomes. Patients with uncomplicated grade 1 hypertension experience decreased risk of stroke and death when lowering blood pressure by an average of 3.6 mmHg systolic, and 2.4 mmHg diastolic (3). Targeting reductions in blood pressure, as well as underlying mechanisms, is key to an integrative treatment plan.

Based on current research findings presented below, the ingredients in this protocol have demonstrated efficacy in improving blood pressure profile.

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About the Protocol

Magnesium Citrate

Recommended dose: 300-450 mg of elemental magnesium, total per day, 1 to 6 months (4-5)

Magnesium in the citrate form. Magnesium is a cofactor for some 300 enzymes in the body, and acts in concert with calcium.

Garlic Complex (Allium sativum)

Recommended Dose: 300-960 mg, total per day, minimum 8 to 12 weeks (6-8)

Supports antioxidant defenses and cardiovascular health
Blend of garlic extract and aged fermented black garlic extract with enhanced stability
Standardized for S-allyl-cysteine

Vitamin C (Ascorbic Acid)

Recommended Dose: 500 mg total per day, minimum 6 weeks (9-12)

Supplementation with Vitamin C found a decreased risk of cardiovascular disease and stroke as shown by a decrease in systolic blood pressure (9)
Promotes optimal immune function
Important in collagen production, which enhances skin, nail, and hair health
Supports healthy tissue and cartilage formation, a benefit during wound healing and injury repair
Plays a role in phase I liver detoxification, plus its antioxidant properties help protect against the toxic effects of heavy metals
Helps increase glutathione, a potent antioxidant necessary for supporting phase II liver detoxification

Melatonin, 3mg

Recommended Dose: 2-3 mg, 1-2 hours prior to sleeping, minimum 3 weeks (13-15)

Melatonin is also an important antioxidant which acts as an effective scavenger of free radicals. Various factors may cause melatonin levels to become low, such as inadequate dietary intake of its precursors (tryptophan and serotonin), normal aging, insufficient exposure to natural light, and certain medications.
Melatonin may support a healthy immune and stress response

K+2 Potassium

Recommended Dose: 950-3500 mg (30-90 mmol) total per day, minimum 4 weeks (9,16-18)

K+2 Potassium is a uniquely formulated potassium product composed of potassium bicarbonate and potassium bound to the amino acid glycine, which gives the product optimum potency, stability and tolerability. This alkalinizing formula provides nutritional support to help maintain healthy blood pressure levels.
Improvements in blood pressure were observed after 6 weeks of supplementation with potassium; 30 mmol of potassium citrate per day resulted in a decrease in mean blood pressure by 5.22 mmHg, while potassium chloride demonstrated a decrease by 4.70 mmHg (17).

References

1.Noubiap, J. J., Nansseu, J. R., Nyaga, U. F., Sime, P. S., Francis, I., & Bigna, J. J. (2019). Global prevalence of resistant hypertension: a meta-analysis of data from 3.2 million patients. Heart , 105(2), 98–105. https://pubmed.ncbi.nlm.nih.gov/30087099/ 2.Cicero, A. F. G., Grassi, D., Tocci, G., Galletti, F., Borghi, C., & Ferri, C. (2019). Nutrients and Nutraceuticals for the Management of High Normal Blood Pressure: An Evidence-Based Consensus Document. High Blood Pressure & Cardiovascular Prevention: The Official Journal of the Italian Society of Hypertension, 26(1), 9–25. https://pubmed.ncbi.nlm.nih.gov/30671873/ 3.Sundström, J., Arima, H., Jackson, R., Turnbull, F., Rahimi, K., Chalmers, J., Woodward, M., Neal, B., & Blood Pressure Lowering Treatment Trialists’ Collaboration. (2015). Effects of blood pressure reduction in mild hypertension: a systematic review and meta-analysis. Annals of Internal Medicine, 162(3), 184–191. https://pubmed.ncbi.nlm.nih.gov/25531552/ 4.Dibaba, D. T., Xun, P., Song, Y., Rosanoff, A., Shechter, M., & He, K. (2017). The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: a meta-analysis of randomized controlled trials. The American Journal of Clinical Nutrition, 106(3), 921–929. https://pubmed.ncbi.nlm.nih.gov/28724644/ 5.Zhang, X., Li, Y., Del Gobbo, L. C., Rosanoff, A., Wang, J., Zhang, W., & Song, Y. (2016). Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension, 68(2), 324–333. https://pubmed.ncbi.nlm.nih.gov/27402922/ 6.Nakasone, Y., Nakamura, Y., Yamamoto, T., & Yamaguchi, H. (2013). Effect of a traditional Japanese garlic preparation on blood pressure in prehypertensive and mildly hypertensive adults. Experimental and Therapeutic Medicine, 5(2), 399–405. https://pubmed.ncbi.nlm.nih.gov/23404465/ 7.Ried, K., Frank, O. R., & Stocks, N. P. (2010). Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. Maturitas, 67(2), 144–150. https://pubmed.ncbi.nlm.nih.gov/20594781/ 8.Sobenin, I. A., Andrianova, I. V., Fomchenkov, I. V., Gorchakova, T. V., & Orekhov, A. N. (2009). Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension. Hypertension Research: Official Journal of the Japanese Society of Hypertension, 32(6), 433–437. https://pubmed.ncbi.nlm.nih.gov/19390538/ 9.Fotherby, M. D., Williams, J. C., Forster, L. A., Craner, P., & Ferns, G. A. (2000). Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons. Journal of Hypertension, 18(4), 411–415. https://pubmed.ncbi.nlm.nih.gov/10779091/ 10.Guan, Y., Dai, P., & Wang, H. (2020). Effects of vitamin C supplementation on essential hypertension: A systematic review and meta-analysis. Medicine, 99(8), e19274. https://pubmed.ncbi.nlm.nih.gov/32080138/ 11.Hajjar, I. M., George, V., Sasse, E. A., & Kochar, M. S. (2002). A randomized, double-blind, controlled trial of vitamin C in the management of hypertension and lipids. American Journal of Therapeutics, 9(4), 289–293. https://pubmed.ncbi.nlm.nih.gov/12115017/ 12.Juraschek, S. P., Guallar, E., Appel, L. J., & Miller, E. R., 3rd. (2012). Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. The American Journal of Clinical Nutrition, 95(5), 1079–1088. https://pubmed.ncbi.nlm.nih.gov/22492364/ 13.Scheer, F. A. J. L., Van Montfrans, G. A., van Someren, E. J. W., Mairuhu, G., & Buijs, R. M. (2004). Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension, 43(2), 192–197. https://pubmed.ncbi.nlm.nih.gov/14732734/ 14.Grossman, E., Laudon, M., Yalcin, R., Zengil, H., Peleg, E., Sharabi, Y., Kamari, Y., Shen-Orr, Z., & Zisapel, N. (2006). Melatonin reduces night blood pressure in patients with nocturnal hypertension. The American Journal of Medicine, 119(10), 898–902. https://pubmed.ncbi.nlm.nih.gov/17000226/ 15.Cagnacci, A., Cannoletta, M., Renzi, A., Baldassari, F., Arangino, S., & Volpe, A. (2005). Prolonged melatonin administration decreases nocturnal blood pressure in women. American Journal of Hypertension, 18(12 Pt 1), 1614–1618. https://pubmed.ncbi.nlm.nih.gov/16364834/ 16.Binia, A., Jaeger, J., Hu, Y., Singh, A., & Zimmermann, D. (2015). Daily potassium intake and sodium-to-potassium ratio in the reduction of blood pressure: a meta-analysis of randomized controlled trials. Journal of Hypertension, 33(8), 1509–1520. https://pubmed.ncbi.nlm.nih.gov/26039623/ 17.Braschi, A., & Naismith, D. J. (2008). The effect of a dietary supplement of potassium chloride or potassium citrate on blood pressure in predominantly normotensive volunteers. The British Journal of Nutrition, 99(6), 1284–1292. https://pubmed.ncbi.nlm.nih.gov/18053306/ 18.Filippini, T., Violi, F., D’Amico, R., & Vinceti, M. (2017). The effect of potassium supplementation on blood pressure in hypertensive subjects: A systematic review and meta-analysis. International Journal of Cardiology, 230, 127–135. https://pubmed.ncbi.nlm.nih.gov/28024910/